Drug eruption - Erupcija Droge
☆ U rezultatima Stiftung Warentest iz Njemačke za 2022., zadovoljstvo potrošača s ModelDermom bilo je samo malo niže nego s plaćenim konzultacijama o telemedicini.
Erupcija Droge (Drug eruption) karakterizira djelovanje na cijelo tijelo.
References
Kožne reakcije uzrokovane lijekovima, poznate kao erupcije na lijek, ponekad mogu biti teške. Ove ozbiljne reakcije, nazvane severe cutaneous adverse drug reactions (SCARs) , smatraju se opasnima po život. Oni uključuju uvjete poput Stevens-Johnson syndrome (SJS) , toxic epidermal necrolysis (TEN) , acute generalized exanthematous pustulosis (AGEP) , and drug reaction with eosinophilia and systemic symptoms (DRESS) . Iako su SCARs rijetke, oko 2% hospitaliziranih pacijenata ih doživljava.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
Na odjel dermatologije javila se 31-godišnja žena s bezbolnom crvenom mrljom na vrhu desnog stopala. Uzela je jednu dozu doksiciklina (100 mg) dan prije, nakon tretmana ožiljaka od akni pikosekundnim laserom. Prošle godine doživjela je sličan problem na istom mjestu nakon što je uzela istu dozu doksiciklina nakon laserskog tretmana. Nema značajnu medicinsku povijest niti druge simptome, poput vrućice, lokalno ili u cijelom tijelu.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
Stevens-Johnson syndrome (SJS) i toxic epidermal necrolysis (TEN) dva su oblika ozbiljne kožne reakcije, koja se razlikuju od drugih stanja kože poput multiforme eritema i stafilokoknog sindroma opečene kože, kao i od reakcija na lijekove. SJS/TEN je rijetka i teška reakcija koja uzrokuje rašireno oštećenje kože i sluznice, često sa sustavnim simptomima. U više od 80% slučajeva uzrok su lijekovi.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Erupcije lijeka dijagnosticiraju se uglavnom na temelju povijesti bolesti i kliničkog pregleda. Biopsija kože, krvni testovi ili imunološki testovi također mogu biti korisni.
Primjeri uobičajenih lijekova koji uzrokuju erupciju su antibiotici i drugi antimikrobni lijekovi, sulfanilamidni lijekovi, nesteroidni protuupalni lijekovi (NSAID), kemoterapijski agensi za zloćudne bolesti, antikonvulzivi i psihotropni lijekovi.
○ Dijagnostika i liječenje
Ako imate groznicu (povišenu tjelesnu temperaturu), trebate što prije potražiti liječničku pomoć. Sumnjivi lijek treba prekinuti (npr. antibiotici, nesteroidni protuupalni lijekovi). Prije posjeta bolnici, oralni antihistaminici poput cetirizina ili loratadina mogu pomoći kod svrbeža i osipa.
#Cetirizine [Zytec]
#LevoCetirizine [Xyzal]
#Loratadine [Claritin]
Test krvi (KKS, LFT, broj eozinofila)
Oralni steroidi i antihistaminici uz liječnički recept